低分子肝素钙联合阿魏酸钠治疗老年不稳定型心绞痛临床观察

Nadroparin Calcium plus Sodium Ferulate for Unstable Angina Pectoris in Senile Patients

目的:观察低分子肝素钙联合阿魏酸钠治疗老年不稳定型心绞痛的疗效。方法:选取2009年1月—2011年1月解放军第313医院收治的老年不稳定型心绞痛患者共160例,以随机抽样法分为实验组和对照组,在按照常规口服肠溶阿司匹林、血管紧张素转换酶抑制剂和硝酸异山梨醇酯的基础上,实验组给予低分子肝素钙和阿魏酸钠治疗,对照组给予丹参注射液治疗。结果:实验组临床疗效的总有效率明显高于对照组(90.00%vs.81.25%,P<0.05);实验组患者的心电图疗效总有效率明显高于对照组(88.75%vs.68.75%,P<0.05);治疗后实验组患者的心绞痛发作次数、持续时间、硝酸甘油用量均明显少于对照组(P<0.05)。结论:低分子肝素钙联合阿魏酸钠治疗老年不稳定心绞痛,其起效快、疗效好、安全性高,值得在临床上推广应用。

OBJECTIVE： To evaluate the efficacy of Nadroparin Calcium plus sodium ferulate for senile patients with unstable angina pectoris.METHODS： From Jan 2009 to Jan 2011,a total of 160 patients with unstable angina pectoris in our hospital were randomized to either control group or experiment group.The experimental group received Nadroparin Calcium plus sodium ferulate in addition to the routine therapies containing enteric-coated aspirin,angiotensin converting enzyme inhibitor（ACEI） and isosorbidi dinitras,and the control group received Danshen injection.RESULTS： The total effective rate of experiment group was significantly higher than in the control group（90.00% vs.81.25%,P〈0.05）.The total effect rate in terms of electrocardiographic efficacy in the experiment group was significantly higher than in the control group（88.75% vs.68.75%,P〈0.05）.After treatment,the frequency and duration of angina pectoris attacks and nitroglycerin dosage in the experiment group were significantly less than in control group.CONCLUSION： Nadroparin calcium plus sodium ferulate is characterized by fast onset of efficacy,good efficacy and safety,which is thus worthy of clinical recommendation.