2009—2011年224例药品不良反应报告分析

Adverse Drug Reactions During 2009-2011:Analysis of 224 Cases

目的:探索医院药品不良反应(ADR)报告和监测工作规律和新模式。方法:回顾2009—2011年ADR报告共224例,从不同角度分析比较各年度ADR报告特点。结果:报告数量逐年增加;医生是报告的主要群体;内科报告数量高于外科数量;224例ADR中,男女比例为1∶1.21;21～30岁和>70岁年龄段患者发生ADR数量居多,并有男女比例的差异;>70岁患者发生ADR报告数量占每年的报告总数比例最大。结论:医院ADR报告数量与医院收治数量不匹配,需要通过多种途径,提高监测员队伍的综合素质和积极性;应用新方法、新模式进行数据的采集和分析,推进医院ADR监测工作。

OBJECTIVE： To study the regular pattern and new mode regarding the reporting and monitoring on adverse drug reactions（ADRs） in hospital.METHODS： A total of 224 ADR case reports collected during 2009-2011 were analyzed from different angle with regard to the characteristics of ADR reports.RESULTS： The number of ADR reports increased year on-year.The ADRs were mainly reported by clinicians.There were more ADR reports from internal department than from surgical department.Of the 224 cases,the ratio of male to female was 1∶1.21,with the patients aged between 21 and 30 years or over 70 years showing the highest proportion and there was difference in male/female ratio.The patients aged 〉70 took the higher proportion in terms of number of annual ADR cases.CONCLUSION： The number of hospital ADR reports doesn’t match the number of admission cases.It is important to adopt multiple approaches to enhance monitoring staff’s comprehensive quality and enthusiasm and adopt new approach and mode to collect and analyze data and facilitate hospital ADR monitoring work.