音频处理技术自动定量估测肺动脉压力、肺血流量及全肺阻力的研究

Study on the auto estimation of pulmonary artery pressure,flow and resistance by audio signal processing technique

目的 评价音频处理技术 (ASPT)自动定量估测肺动脉收缩压 (PASP)、平均压 (PAMP)、肺血流量 (QP)及全肺阻力 (TPR )的准确性。方法 对 60例先心病患儿 ,应用ASPT和多普勒超声技术(DE) ,根据改良的肺动脉 /主动脉血流时间间期比法及容积血流测量技术估测PASP、PAMP、QP,按Poiseuille公式计算TPR ,并与心导管测值对比。结果 ASPT估测PASP、PAMP、QP、TPR所需时间短于DE所需时间 ( P <0 .0 1)。PASP、PAMP、QP、TPR的心导管测值与ASPT估测值高度相关 ( r =0 .96、0 .96、0 .82、0 .87,P <0 .0 0 1) ,且重复性较好 ;与DE估测值中等程度相关 (r =0 .86、0 .86、0 .71、0 .75 ,P<0 .0 0 1)。结论 ASPT可准确地自动定量估测PASP、PAMP、QP、TPR。

Objective To assess the accuracy of audio signal processing technique(ASPT) in noninvasive automatic estimation of systolic pulmonary arterial pressure(PASP),mean pulmonary arterial pressure(PAMP),flow(Q P),and resistance(TPR).Methods Comparative studies among Doppler echocardiography(DE),ASPT and cardiac catheterization for predicting PASP,PAMP,Q P,and TPR had been done in 60 children with congenital heart disease.Results ASPT derived PASP,PAMP,Q P,and TPR correlated closely with those measured by cardiac catheterization(r= 0.95 , 0.96 , 0.82 , 0.87 ,P< 0.001 ),and by DE(r= 0.86 , 0.86 , 0.71 , 0.75 ,P< 0.001 ).Conclusions PASP,PAMP,Q P,and TPR could be auto estimated noninvasively adopting modified F PA /F AO and poiseuille formula by ASPT.