小儿退热栓体外溶出度及兔体内生物利用度的考察

Investigation on the Dissolution in Vitro and the Rabbit Bioavailality of Paracetamol Suppositories

对国内四个药厂生产的小儿退热栓体外溶出度及兔体内生物利用度进行对比研究。体外参数T_(50)、T_4及体内参数C_m、T_m、AUC_(0→∞)经方差分析有极显著差异.

The dissolution in vitro and the rabbit bioavailability of the paracetamolsuppositories erom four factories were Studied an compared.By statistical treat-ment parameters in vitro(T_(50),Td)and in vivo(Cm,Tm,AUCo-∞)were differentsignificantly.