摘要
在6名健康志愿者中,用荧光偏振免疫分析法测定丙戊酸钠血药浓度,并探讨了丙戊酸钠缓释片的药物动力学。结果表明,它的滞后时间是0.22±0.11h,半衰期是21.66±4.25h,达峰时间是9.64±2.31h,峰浓度是31.82±5.51μg/ml,曲线下面积是1391.90±224.26μg·h/ml。
The Pharmacokinetics of sustained-release sodium valproate was studied in 6healthy volunteers.It was found that its Lag Time is 0.22±0.11h,T1/2 is 21.66±4.25 h,Tm is 9.64±2.31μg/ml,AUC is 1391.90+224.26 μg.h/ml.The levels of val-proic acid in serum are determinated with fluorescence polarization immunoassay.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
1990年第12期535-537,共3页
Chinese Journal of Hospital Pharmacy
关键词
丙戊酸钠
血药浓度
药物动力学
sustained-release sodium ralproate
pharmacokinetics
fluorescence polarization immunoassay
serum drug concentration
