肺癌患者凝血功能与肺癌分期的关系

The Relationship Between Blood Coagulation Function and Lung Cancer Staging

目的:探讨肺癌患者凝血功能与肺癌分期的关系。方法:采用ELISA、免疫比浊法检测140例晚期恶性肿瘤患者和30例正常人的凝血、抗凝活性相关的实验室指标,包括血浆纤维蛋白原(Fb),抗凝血酶Ⅲ(AT-Ⅲ),血管性血友病因子(vWF),D-二聚体(D-D)。结果:晚期恶性肿瘤患者的血浆D-D、Fb、AT-Ⅲ、vWF抗原的水平较正常人显著升高;在肺癌Ⅲ期、Ⅳ期与Ⅰ期相比明显增高(P<0.05),差异有统计学意义;Ⅱ期与Ⅰ期相比增高不明显(P>0.05),差异没有统计学意义。结论:肺癌患者存在凝血、抗凝、纤溶系统的激活,机体呈现高凝状态,并且高凝状态与肺癌临床分期呈正相关。

Objective To explore the relationship between the function of blood coagulation in patients with lung cancer and lung cancer staging. Methods ELISA assay for detection of 140 cases of advanced malignant tumor patients and 30 cases of normal human blood coagulation and anticoagulation activity related to laboratory indexes, including plasma fibrinogen （Fb）, antithrombin Ⅲ （AT- Ⅲ ）, van Willebrand factor （ vWF ）, D-D （ D-dimer ）. Results The patients with advanced malignant plasma D-dimer, fibrino- gen, thrombin antithrombin Ⅲ and yon Willebrand factor antigen levels were significantly elevated and indexes in patients with lung cancer clinical staging with increased. Conclusion The patients with lung cancer usually presence of coagulation, anticoagulation and activation of fibrinolytic system, exists high coagulation state, thus, high coagulation state and clinical staging of lung cancer was posi- tively related to.