支气管哮喘患者血清TNF-α、IL-8和IgE水平的相关性分析

Correlative Analysis of Serum TNF-α,IL-8 and IgE Levels in Patients with Bronchial Asthma

目的:探讨支气管哮喘患者血清TNF-α、IL-8和IgE的关系及意义。方法:采用酶联法对33例支气管哮喘患者进行了血清TNF-α、IL-8和IgE检测,并与35名正常人作比较。结果:支气管哮喘患者血清TNF-α、IL-8和IgE水平均非常显著地高于正常人组(P<0.01),经治疗1个月后与正常人组比较仍有显著性差异(P<0.05),血清IgE水平与TNF-α、IL-8水平呈显著正相关(r=0.5712、0.6018,P<0.01)。结论:检测血清TNF-α、IL-8和IgE含量可作为判断支气管哮喘病情的严重程度和治疗效果的重要指标。

Objective To explore the relationship between serum TNF-ot, IL-8 and IgE levels in patients with bronchial asthma and their significance. Methods SerumTNF-α, IL-8 and IgE levels with ELISA in 33 patients with bronchial asthma and 35 normal controls. Results Before treatment serum TNF-α,IL-8 and IgE levels were measured significantly higher than those in controls（P 〈 0.01 ）, after treatment for 1 month, the levels still higher than those in controls（P 〈0.05）, serum IgE levels were positive correlated with TNF-α, IL-8 and IgE levels （r = 0. 5712 ,0. 6018 , P 〈 0.01 ）. Conclusion Detection of serum TNF-α, IL-8 and IgE levels were useful for assessment of the therapeutic efficacy.