川芎嗪联合前列地尔治疗背景性糖尿病视网膜病变疗效的临床观察

The Effectiveness of Ligustrazine Combined with Alprostadil Treatment on Background Diabetic Retinopathy

目的:探讨川芎嗪(Ligustrazine)联合前列地尔(Alprostadil)治疗背景性糖尿病视网膜病变(Diabetic retinopathy,DR)的作用与疗效。方法:收集近年我院糖尿病伴背景性DR共73例(112只眼),分别按治疗中应用川芎嗪联合前列地尔或拜阿司匹林分为治疗组与对照组,比较两组治疗前后患者眼底病变改善情况。结果:川芎嗪联合前列地尔的治疗组疗效比拜阿司匹林的对照组好;眼底荧光检查表明,治疗组眼底病变改善明显好于对照组,差异显著(P<0.05)。结论:川芎嗪联合前列地尔对DR有较好的疗效。

Objective： Diabetic retinopathy（DR） is a blinding oculopathy which seriously influence human health and the leading cause of blind in old patient beyond the age of 50 in China.This study aimed to observe the therapy effectiveness of Ligustrazine combined with Alprostadil for background DR and discuss the mechanism.Methods：Select background DR patients（n=73）.To treat the retinopathy eyes（n=112）,we set treatment group by using Ligustrazine combined with Alprostadil and control group by using Ligustrazaine and Aspirin.Compare the eyeground pathological changes before and after treatment.Results：Treatment using Ligustrazine combined with Alprostadil had a better performance after thyrapy compared before than Ligustrazaine and Aspirin.The overall efficacy was 68.97% in treatment group,while 38.89% in control group.Fluorescein fundus angiography showed that improvement for treatment was obvious better than control,（P〈0.05）.Conclusion：Ligustrazine combined with Alprostadil therapy is effective for treat diabetic background retinopathy.Conservative medical management plays an important role in DR.