印迹基因Igf2对胎盘发育和胎儿生长的影响

The Influence of Imprinted Gene Igf2 on Placental Development and Fetal Growing

基因组印迹是哺乳动物正常生长发育和行为的基础。印迹基因胰岛素样生长因子2(insulin-like growth factors II,Igf2)对胎盘及胎儿的营养供应起着不可或缺的影响。它影响胎盘的大小、形态和营养转运功能,进而影响胎儿生长的营养供应。因此Igf2表达的变化对发育编程具有重要意义,对胎盘发育和胎儿生长起着重要的作用。

Genomic imprinting is the basic of normal growing development and activity in mammal.Insulin-like growth factors II（Igf2）plays an important role in nutrition supply of placenta and fetus.It affects the size,modality and nutrient transfer function in placenta,and then influence nutrient transfer of fetus growing.Therefore,the changes of Igf2 have great significance on developmental programming,also is important to placental development and fetal growing.