摘要
消炎痛可引起小鼠胃粘膜损伤,在一定剂量范围内,其剂量和胃粘膜损伤程度之间有明显的量效关系。在引起胃粘膜损伤时,胃组织胺含量相应增加,大剂量重度损伤时尤为明显。预先用甲氰咪胍灌胃,可明显减轻损伤并降低组织胺含量。提示组织胺参与消炎痛致胃粘膜损伤过程并对损伤产生一定影响。
In the present study, it was indicated that indocin could induce gastric injury rapidly. In certain range of doses the degree of mucosal injury was correlated with the dose of the drug. The gastric histamine content increased during injury, especially in large doses. Pre-administration of cimetidine could reduce significantly the injury and the histamine content of gastric mucosa. It is considered that histamine may play a certain role in the mechanism of indocin-induced gastric mucosal injury.
出处
《中国应用生理学杂志》
CAS
CSCD
1990年第1期55-58,共4页
Chinese Journal of Applied Physiology
