ICAM-1在先天性血管瘤激光干预前后的表达及意义

The Expression and Significance of ICAM-1 in Congenital Hemangioma Before and After the Laser Intervention

目的探讨细胞间黏附分子-1(ICAM-1)在先天性血管瘤患儿长脉宽1064nm Nd:YAG激光干预前后表达变化的临床意义。方法采用ELISA及免疫组化方法测定50例先天性血管瘤患儿激光治疗前及治疗1个月后血清与血管瘤组织中ICAM-1的水平及健康对照组患儿血清和皮肤组织中的ICAM-1水平,将先天性血管瘤患儿术前分别与健康体检者,激光干预后sICAM-1及mICAM-1的表达水平进行比较。结果激光干预前先天性血管瘤患儿血清sICAM-1的水平(566.92±51.39)μg/L明显高于健康对照组(218.01±38.43)μg/L,差异有统计学意义(P<0.01);干预后1个月sICAM-1水平(418.40±55.89)μg/L较干预前有显著下降,差异有统计学意义(P<0.01)。干预前血管瘤组织中mICAM-1显著高于干预后及正常皮肤组织,干预后1个月mICAM-1表达较干预前明显减弱,差异均有统计学意义(P均<0.01)。结论 ICAM-1可能是先天性血管瘤分期诊断和疗效观察的一个临床生物检测指标,进一步的研究有助于婴幼儿先天性血管瘤的诊断和治疗。

Objective To explore the changes of ICAM-1 in children with congenital hemangioma before and after the long pulse 1 064 nmNd：YAG laser treatment. Methods Levels of ICAM-1 in serum and tissue before surgery and 1 month after were detected using ELISA and immunohistochemistry in 50 cases of children with congenital hemangioma , and healthy children were taken as control group. Results The level of sICAM-1 and mICAM-1 in children with congenital hemangioma was significantly higher than that in the control group, and the level after treatment were lower than those before treatment. There were statistically significant differences （P 〈 0.01 ）. Conclusion ICAM-1 may be a clinical bioassay indicators of diagnosis and efficacy in congenital vascular tumor staging, further study will contribute to the diagnosis and treatment of infants with congenital hemangioma.