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白细胞去除术对内毒素血症犬肺损伤的影响及机制研究

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摘要 急性肺损伤（acutelunginjury，ALI）／ARDS发病率和病死率仍居高不下。多形核白细胞（polymorphonu—clearleucocyte，PMN）在肺内积聚、活化，相应产物增加在肺实质细胞损伤中的关键作用已获得公认。笔者利用连续血流白细胞分离机部分去除内毒素血症犬外周血白细胞，观察部分白细胞去除对内毒素血症犬ALI／ARDS发生的影响，并通过其对血清弹性蛋白酶（neu-trophilelastase，NE）及NF-κB的影响进一步探讨白细胞去除影响ALI发生的机制。
作者 贺志高 周顺刚 何静 陈方祥 黄显凯
机构地区 兰州军区乌鲁木齐总医院重症医学科 第三军医大学附属大坪医院野战外科研究所输血中心 创伤中心
出处 《中华创伤杂志》 CAS CSCD 北大核心 2012年第6期564-567,共4页 Chinese Journal of Trauma
基金 军队“十一五”课题资助项目（082024）
关键词 白细胞去除术 内毒素血症 急性肺损伤 ALI/ARDS 肺实质细胞损伤 多形核白细胞 外周血白细胞 白细胞分离机
分类号 R563.8 [医药卫生—呼吸系统]
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参考文献17

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二级参考文献8

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共引文献18

中华创伤杂志
2012年 第6期

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