参黄散对腹部术后小鼠小肠动力障碍的影响

Effect of Shenhuang Powder on Intestinal Motility Disorder in Mice after Abdominal Surgery

目的:探讨参黄散对小鼠腹部术后小肠动力障碍的治疗效果。方法:取90只健康雄性ICR小鼠,随机分模型组、参黄散组和假手术组,每组再随机分为2、4、6h组,每组10只。模型组和参黄散组小鼠制备成小肠动力障碍模型,假手术组仅行剖腹探查术。造模成功后30min,治疗组予以参黄散敷脐治疗,假手术组和模型组予以等体积量细沙包敷脐。在2、4、6h点检测血清胃动素和生长抑素水平及墨汁推进率。结果:参黄散组在6h点墨汁推进率明显高于模型组(P<0.05),血清胃动素和生长抑素水平在2h和4h点明显高于假手术组和模型组(P<0.05)。结论:参黄散敷脐能改善腹部术后小鼠小肠动力障碍。

Objective To investigate the effect of Shenhuang Powder on intestinal motility disorder after ab- dominal surgery in mice. Methods Ninety healthy male ICR rats were randomly divided into the model group, Shenhuang powder group and the sham operation group. The model group and Shenhuang powder group were pre- pared into the intestinal motility disorder models. In the sham operation group only exploratory laparotomy was applied. The above-mentioned groups were then randomly divided into 2 h,4 h and 6 h groups. Thirty minutes after the model was successfully established, in the Shenhuang powder group Shenhuang powder oblatum was ap- plied on bellybutton while equal volume of fine sandbag were used in the sham operation group and the model group. At the end of 2 h, 4 h and 6 h after treatment, the serum levels of motilin and somatostatin and car- bon-ink transit rate were detected. Results The carbon-ink transit rate in Shenhuang powder group was sig- nificantly higher than that in model group at 6 hours after operation. The serum levels of motilin and somatosta- tin were significantly higher than those in sham operation group and model control group at 2 and 4 hours after operation （P 〈 0.05）. Conclusion Shenhuang powder can promote the recuperation of enterokinesia in mice after abdominal surgery.