c-FLIP在前列腺癌过表达的研究进展

Progress of c-FLIP overexpression in prostatic carcinoma

前列腺癌（prostaticcarcinoma，Pea）为欧美发达国家男性最常见的恶性肿瘤之一，是老年男性恶性肿瘤死亡的首要原因。在我国随着社会人口老龄化、前列腺特异性抗原（prostate specificantigen，PSA）普查和临床诊疗技术的提高，PCa的发病率呈上升趋势。

Cellular FLICE-inhibitory protein （c-FLIP） is a key anti-apoptotic regulator that inhibits death receptor （DR） signal pathway mediated by suppressing procaspase-8 activation. c-FLIP has been found to be elevated in prostatic carcinoma （PCa）, and there is a strong correlation between the overexpression of c-FLIP and PCa. In the present paper, we review the links beteween c-FLIP and androgen receptor （AR） signal pathway, which regulate and promote the survival of androgen-independent prostate cancer （AIPC） and describe the possibility of c-FLIP as a therapeutic target of PCa.