烧伤早期微循环功能障碍的本质——“外压”、“内堵”

Nature of Microcirculation Dysfunction of Burn Wounds at an Early Stage:External Pressure and Internal Blocking

目的探讨烧伤早期微循环功能障碍的本质,为烧伤的发病和治疗提供理论依据。方法对以往完成的有关微循环的临床和实验研究进行归纳分析,总结烧伤局部和全身微循环的形态学、组织间液含水量、血流动力学、血液流变学等多项指标的变化,分析组织细胞变性、坏死的发生机制。结果烧伤后局部和全身毛细血管通透性升高,组织间液含水量和压力上升,毛细血管内出现高凝状态和微血栓形成。结论严重烧伤早期微循环功能障碍的本质是"外压"、"内堵",从而诱发细胞变性、坏死,为烧伤发病和再生疗法提供理论依据。

Objective To explore the essence of microcirculation dysfunction of burn wounds at an early stage so as to provide theoretic evidence for the occurrence and treatment of burns. Methods By summarizing and analyzing the previous clinical and experimental studies related to microcirculation to see the topical and systemic microcirculation changes in terms of morphology, water content of interstitial fluid, haemodynamics, hemarheology and etc, and to further analyze the pathogenesis of tissue cell degeneration and necrosis. Results The permeability of local and systemic capillaries, and the water content of the interstitial fluid and interstitial fluid pressure were all elevated, the hypercoagulable state and microthrombus were observed in the capillaries. Conclusion The essence of mlcrocirculation dysfunction of severe burn wounds at an early stage is the internal pressure and external blocking, which in turn induces the degeneration and necrosis of cells. This study would provide theoretic evidence for the burn pathogenesis and its regenerative therapy treatment.