摘要
Fawn-Hooded(FH/Wjd)大鼠是一种近交系大鼠,属于FH大鼠中的一个亚系,具备饮酒量大(>5 g.kg-1.d-1)和酒精偏爱度高(>65%)的特点,存在明显的酒精剥夺效应,并可在短期内建立操作性自身饮酒行为,是一种理想的先天性嗜酒动物模型。此外,FH/Wjd大鼠中枢神经系统5-羟色胺(5-hydroxytryptamine,5-HT)功能低下,在强迫游泳实验中,FH/Wjd大鼠的行为绝望表现明显。因此,可以作为研究抑郁症的动物模型。
The Fawn-Hooded（FH/Wjd） rat is one of the FH inbred strain.Considered as an ideal animal model for the study of heavy drinking,the FH/Wjd rats exhibit several characteristics,including excessive voluntary intake of alcohol（〉5 g·kg-1·d-1）,high preference to ethanol（〉65%）,significant alcohol deprivation reaction,as well as easily established operational self-administration drinking behavior.Furthermore,the hypo-function of 5-HT in the central nervous system makes the FH/Wjd rats behave quite specially in animal behavioral tests.For example,the FH/Wjd rats show noticeable immobility in the forced swimming test,similar to features in the depression animal model.Thus,the FH/Wjd rats can serve as an animal model for studies on depression.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2012年第7期893-897,共5页
Chinese Pharmacological Bulletin
基金
国家自然科学基金资助项目(No 30870894)
国家重大基础研究发展计划(973计划)资助项目(No2009CB522000)
十二五科技支撑计划资助项目(No2011BAK04B08)
