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α-晶状体蛋白的结构和功能及基因学研究进展 被引量：1

Recent research progress in the function,structure and genetics of alpha-crystallin
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摘要 α-晶状体蛋白包括αA-,αB-晶状体蛋白,是哺乳动物晶状体的主要蛋白,属于小热休克蛋白家族成员,具有分子伴侣功能,可以抑制变性蛋白质的凝聚和酶的失活。α-晶状体蛋白基因突变可导致白内障和肌病。本文对α-晶状体蛋白的分布、结构、功能以及基因学等方面综述。 Alpha-crystallin consists of two subunits： αA- and αB- crystalline, and is a major protein component of the mammalian eye lens. Being a member of the small heat-shock protein family, alpha-crystallin possesses chaperone-like function. It prevents aggregation of partially denatured proteins and the inactivation of enzymes. Mutations in alpha-crystallin genes can cause cataract and myopathy. This review focused on some of the expression, structure, function and genetics of alpha-crystallin.
作者 屈凌寒 韩笑 刘阁 严宏
机构地区 第四军医大学口腔医学系 第四军医大学唐都医院眼科
出处 《国际眼科杂志》 CAS 2012年第7期1301-1303,共3页 International Eye Science
基金 军队医学杰出人才基金(No.04J011)~~
关键词 Α-晶状体蛋白 分子伴侣 基因学 白内障 alpha-crystallin molecular chaperones genetics cataract
分类号 R776.1 [医药卫生—眼科]
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参考文献30

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共引文献33

同被引文献34

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国际眼科杂志
2012年 第7期

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