IGF-1参与调控眼球生长的研究进展

Research progress of IGF-1 in regulating eye's growth

眼球生长是一个在视觉信号诱导下的主动过程,视网膜、脉络膜和巩膜都参与了这一过程,并且有多种信号分子在调控眼球生长的过程中发挥了重要作用。IGF-1作为一种强有力的促生长因子在维持和控制细胞生长、增殖、分化、成熟和再生等方面具有重要作用,在眼内也有广泛的表达,并且参与了眼科多种疾病的发生发展。近年来,它在调控眼球生长过程中发挥的作用受到了广泛的关注。本文对IGF-1在促进眼球主动生长的调控作用展开综述。

Eyes growth is an active process relies on the visual guidance. The retina,choroid and sclera are all involved in this process. There are a variety of signaling molecules that play an important role in regulating the eyes growth. Insulin-like growth factor-1 （IGF-1） is a powerful growth-promoting factor, and its role in the maintenance and controlling of cells growth, proliferation, differentiation, maturation and regeneration has been well recognized. There is also a wide range of expression of IGF-1 in eyes, which participate as a contributor in the occurrence and development of eye diseases. In recent years, its role of regulating the eyes growth has been widespread concerned. IGF-1s recognized role in regulating the eyes growth is reviewed in this paper.