变异型Guillain-Barre综合征的临床特点

Clinical features of variant Guillain-Barre syndrome

目的探讨变异型Guillain-Barre综合征(GBS)的临床特点。方法回顾性分析14例变异型GBS患者的临床资料。结果本组10例为女性,4例为男性;均为急性或亚急性起病,病前11例有相关诱因;临床表现为多脑神经型、急性运动轴索型、Miller-Fish综合征及全自主神经功能障碍型。12例行腰椎穿刺术,11例脑脊液蛋白增高;11例行肌电图检查,9例提示为周围神经源性损害;经个体化治疗所有患者的症状均有改善。结论变异型GBS类型及临床表现多样,以女性患者多见;脑脊液蛋白-细胞分离及肌电图检查为周围神经源性损害有助于诊断。

Objective To explore the clinical features of variant Guillain-Barre syndrome（GBS）.Methods The clinical data of 14 variant GBS patients were retrospectively analyzed.Results In this group,the 10 cases were female and 4 cases were male.The onset was acute or sub-acute.Eleven cases had related incentive factor before onset.The clinical manifestations were presented multiple cranial nerves type,acute motor axonal neuropathy,Miller-Fish syndrome and extensive vegetative nerve functional disturbances.Twelve cases received lumbar puncture and CSF protein was raised in 11 cases.MEG examination was showed that 9 in 12 cases had peripheral neuropathic injury.The syndromes in all the cases were improved after individual treatments.Conclusions The clinical types and manifestations of variant GBS were varied,and female patients are more.The CSF protein-cell separation and peripheral nerves injury by MEG are helpful for the diagnosis.