米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效观察

Observation of the clinical effect of Mifepristone and Marvelon in the treatment of dysfunctional uterine bleeding in postmenopausal women

目的:评价米非司酮与妈富隆治疗围绝经期功能失调性子宫出血的临床疗效。方法:将围绝经期功能失调性子宫出血患者120例随机分为米非司酮组和妈富隆组,治疗随访3个月,比较两组治疗前后调经效果、激素水平变化、子宫内膜厚度、药物副作用等。结果:治疗3个月后,米非司酮组在治疗期间均有效止血,无复发;妈富隆组停药后有撤退性出血,复发率为21.7%;米非司酮组血清激素水平FSH、LH、E2、P较治疗前有所下降,妈富隆组E2、P较治疗前下降;两组子宫内膜厚度均较治疗前变薄,治疗前后比较具有统计学差异(P<0.05)。结论:米非司酮治疗绝经期功能失调性子宫出血较妈富隆疗效确切,值得推广。

Objective：To evaluate the clinical effect of Mifepristone and Marvelon in the treatment of dysfunc- tional uterine bleeding in postmenopausal women. Methods： A total of 120 cases of dysfunctional uterine bleeding in postmenopausal women were randomly divided into Mifepristone and Marverlon group. The effect of regulating menstruation, variance of hermone level, thickness of endometrium and side effect of drugs etc were compared between the two groups before and after the treatment. Results： After treatment for 3 months, the effective hemo- stasis without reoccurrence were observed in Mifepristone group while the withdrawal hemorrhage was observed in Marvelon group with a reoccurrence rate of 21.7%. Levels of serum hormone such as FSH, LH, E2 and P in Mife- pristone group decreased after the treatment while levels of E2 and P in Marvelon group decreased after the treat- ment. The thicknesss of endometrium was reduced significantly after the treatment （ P 〈 0.05 ）. Conclusion： The clinical effect of Mifepristone in the treatment of dysfunctional uterine bleeding in postmenopausal women is better than that of the Marvelon group.