Periostin与上皮源性恶性肿瘤侵袭转移的关系

Association of mesenchyme-specific gene periostin with carcinoma invasion and metastasis: recent progress

Periostin是近年发现的一个新的间质特异基因,其编码蛋白由835个氨基酸组成,相对分子质量约90 000,可促进成骨细胞的增殖、分化和骨膜成骨前体细胞的聚集、黏附及间质平滑肌细胞的迁移,在多种人类正常组织中都有表达。Periostin在肺癌、结肠癌、肝癌、食管癌、乳腺癌、卵巢癌等恶性肿瘤中过表达,可促进肿瘤的存活和血管生成,并可作为肿瘤细胞发生上皮间质转化的标志,其在肿瘤侵袭转移的作用也日益受到关注并取得了一些研究进展。

Periostin is a newly identified mesenchyme-specific gene encoding a protein of 835 amino acids, with a molecular size about 90 000. Periostin can promote proliferation and differentiation of osteoblasts, recruitment and attachment of osteoblast precursors, and migration of stromal smooth muscle cells. Periostin can be found in many normal tissues in humans, and it is over-expressed in lung caner, colon cancer, liver cancer, esophagus cancer, breast cancer, ovarian cancer, and so on. Periostin can promote neoplasm growth and angiogenesis and may serve as a biomarker of epithelial-mesenchymal transition （EMT）. Moreover, the role of periostin in cancer invasion and metastasis is gaining increasing attention and has yielded some progress.