星形胶质细胞升高基因1在肿瘤中的多重调节功能研究进展

Astrocyte elevated gene 1 as a multifunctional regulator in cancer progression

星形胶质细胞升高基因1(astrocyte elevated gene 1,AEG-1)作为重要的癌基因之一,目前已被证实在多种肿瘤的发生发展过程中发挥关键性作用。近十年来研究表明AEG-1在神经母细胞瘤、黑素瘤、肝癌、乳腺癌、前列腺癌等几乎所有器官的恶性肿瘤中均有不同程度过表达,在肿瘤细胞增殖、促进血管生成、肿瘤转化、侵袭和转移以及化疗耐药等方面发挥多重调节作用,其机制涉及到PI3K/Akt、NF-κB等多个信号通路。本文主要综述近年来AEG-1在肿瘤发生发展过程中多重调节作用的相关研究进展,以及将其作为恶性肿瘤治疗新靶点的应用前景。

Astrocyte elevated gene 1（AEG-1）,an important oncogene,has been confirmed to play a crucial role in progression（invasion,metastasis,angiogenesis and chemoresistance,etc） of multiple cancers.Over the past decade,studies have shown that AEG-1 is overexpressed in cancers involving almost all organs,including neuroblastoma,melanoma,HCC,breast,prostate cancer,etc.Moreover,AEG-1 is associated with multiple pathways including PI3K/Akt and nuclear factor-κB（NF-κB）.This review mainly outlines the multiple regulating role of AEG-1 in the development and progression of tumor and to discuss its role as a novel target for treatment of malignant tumors.