莫沙必利联合奥美拉唑治疗反流性食管炎100例分析

目的观察并分析莫沙必利联合奥美拉唑治疗反流性食管炎的临床疗效。方法将100例经内镜确诊的反流性食管炎患者随机平分为治疗组和对照组。治疗组:奥美拉唑20mg,2次/d,口服;莫沙必利5mg,3次/d,口服。对照组:给予奥美拉唑20mg,2次/d,口服。两组的疗程均为8周,观察并记录患者临床症状改善情况以及不良反应发生情况,比较两组的总有效率。结果 8周结束后,两组临床症状改善的总有效率分别为88.0%和70.0%,P<0.05,治疗组的效果明显好于对照组,差异具有统计学意义;两组胃镜下黏膜的愈合情况分别为84.0%和66.0%,P<0.05,差异具有统计学意义;两组不良反应发生率比较差异无统计学意义。结论莫沙必利联合奥美拉唑治疗反流性食管炎具有良好的协同作用,值得临床推广应用。

Objective To observe and analyze the clinical efficacy of the mosapride omeprazole treatment anti-reflux esophagitis.Methods 100 cases of patients with reflux esophagitis diagnosed by endoscopy were randomly equally divided into treatment and control groups.The treatment groups：omeprazole 20 mg,twice a day,oral;mosapride 5 mg three times/d,oral.The control group：omeprazole 20 mg,twice a day,oral.Two groups of treatment were lasted 8 weeks,all was abserved and recorded clinical symptom improvement and adverse events were compared between the two groups total efficiency.Results The clinical symptoms improved after the end of eight weeks,the total efficiency of 88.0% and 70.0% respectively,P〈0.05,treatment group was significantly better than the control group,with statistical significance;treatment group endoscopic mucosalhealing was 84.0% and 66.0%,P〈0.05,statistical significance is obvious;no significant incidence of adverse reactions.Conclusion the mosapride omeprazole in the treatment of reflux esophagitis has a good synergy,is worthy of clinical application.