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锰超氧化物歧化酶与上皮性卵巢癌的相关研究进展 被引量:1

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摘要 从活性氧与恶性肿瘤的关系、活性氧与卵巢癌的相关性,来阐述恶性肿瘤组织活性氧增加,活性氧是卵巢癌诱发因素;活性氧与超氧化物歧化酶(SOD)处于动态平衡,过度表达锰超氧化物歧化酶(MnSOD)可抑制肿瘤细胞生长;对卵巢癌组织中MnSOD表达的意见不统一;抑制MnSOD活性,卵巢恶性肿瘤增生活跃,反之抑制肿瘤生长。MnSOD有可能成为治疗卵巢癌的靶点。
作者 李卫 何援利
出处 《东南大学学报(医学版)》 CAS 2012年第3期382-385,共4页 Journal of Southeast University(Medical Science Edition)
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参考文献28

  • 1HANCOCK J T,DESIKAN R,NEILL S J.Role of reactive oxygen species in cell signalling pathways[J].Biochem Soc Trans,2001,29(Pt 2):345-350.
  • 2GABBITA S P,ROBINSON K A,STEWART C A,et al.Redox regulatory mechanisms of cellular signal transduction[J].Arch Biochem Biophys,2000,376(1):1-13.
  • 3SUZUKI N,KOUSSEVITZKY S,MITTLER R,et al.ROS and redox signaling in the response of plants to abiotic stress[J].Plant Cell Environ,2011,35(2):259-270.
  • 4CHENAIS B,ANDRIOLLO M,GUIRAUD P,et al.Oxidative stress involvement in chemically induced differentiation of K562 cells[J].Free Radic Biol Med,2000,28(1):18-27.
  • 5TOYOKUNI S,OKAMOTO K,YODOI J,et al.Persistent oxidative stress in cancer[J].FEBS Lett,1995,358(1):1-3.
  • 6PELICANO H,CARNEY D,HUANG P.ROS stress in cancer cells and therapeutic implications[J].Drug Resist Updat,2004,7(2):97-110.
  • 7GUPTA A,ROSENBERGER S F,BOWDEN G T.Increased ROS levels contribute to elevated transcription factor and MAP kinase activities in malignantly progressed mouse keratinocyte cell lines[J].Carcinogenesis,1999,20(11):2063-2073.
  • 8OSADA H,TAKAHASHI T.Genetic alterations of multiple tumor suppressors and oncogenes in the carcinogenesis and progression of lung cancer[J].Oncogene,2002,21(48):7421-7434.
  • 9NESS R B,COTTREAU C.Possible role of ovarian epithelial inflammation in ovarian cancer[J].J Natl Cancer Inst,1999,91(17):1459-1467.
  • 10OLSON S H,CARLSON M D,OSTRER H,et al.Genetic variants in SOD2,MPO,and NQO1,and risk of ovarian cancer[J].Gynecol Oncol,2004,93(3):615-620.

二级参考文献9

  • 1郝翠芳,王明正.卵巢恶性肿瘤患者超氧化物歧化酶和脂质过氧化物的测定[J].中华妇产科杂志,1995,30(4):235-236. 被引量:7
  • 2Kahlos K,Paakko P, Kurttila E,et al. Manganese superoxide dismutase as a diagnostic Marker for malignant pleural mesothelioma.Br J Cancer,2000,82(5) : 1022.
  • 3Law EW, Zwacka R,Engelhardt JF, et al. Adenovirus-mediated manganese superoxide dismutase gene transfer to hamster cheel pouch carcinoma cell.Cancer Res, 1997,57(24) :5550.
  • 4Lam EW, Hammad HM,Zwacka R,et al. Immunolocalization and adenoviral vectoc-mediated manganese superoxide dismutase gene transfer to experimental oral tumors.J Dent Res,2000,79(6) : 1410.
  • 5Boher JM, Pujol JL, Grenier J, et al. Markov model and markers of small cell lung cancer: assessing the influence of reversible serum NSE, CYFRA21 - 1 and TPS levels on prognosis[ J]. Br J Cancer, 1999,79(9 - 10) : 1419.
  • 6Kahlos K, Paakko P, Kurttila E, et al. Manganese superoxide dismutase as a diagnostic marker for malignant pleural mesothelioma [J]. Sr J Cancer,2000,82(5) :1022.
  • 7Lam EW, Hammad HM, Zwacka R, et al. Immunolocalization and adenoviral vector - mediated manganese superoxide dismutase gene transfer to experimental oral tumors[ J]. J Dent Res,2000,79(6) : 1410.
  • 8Brechot JM, Chevret S, Nataf J, et al. Diagnostic and prognostic value of Cyfra21 - 1 compared with other tumor markers in patients with non-small lung cancer: a prospective study of 116 patients [ J]. Eur J Cancer,1997,33(3) :385 -391.
  • 9韩素慧.超氧化物歧化酶在卵巢癌诊断及监测中的意义[J].实用妇产科杂志,2003,19(3):177-178. 被引量:3

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