葡萄糖转化酶-1在食管癌前病变中的表达及意义
摘要
葡萄糖转化酶.1(glucosetransporterDrotein1,GLUT-1)是分布最广的介导细胞摄人葡萄糖的主要载体。GLUT-1在许多葡萄糖代谢率高的实质性肿瘤中有较高的表达,并且与肿瘤的发生进展及预后有关。本文结合过碘酸雪夫(PAS)染色,应用免疫组织化学法对72例内镜活检证实的食管正常上皮、单纯性增生、异型增生及鳞状细胞癌及10例食管鳞癌手术标本组织中GLUT-1的表达进行检测,探讨GLUT-1作为临床判断食管上皮异型增生转向癌变的价值。
出处
《实用医技杂志》
2012年第6期618-620,共3页
Journal of Practical Medical Techniques
参考文献10
-
1邓登豪,朱海杭,罗金燕,张军,王康敏,左红梅.内镜下Toluidine Blue和Lugol’s Solution双重染色在食管早期癌和浅表癌诊断中的意义[J].中国内镜杂志,2001,7(2):21-23. 被引量:20
-
2赵卫,任宏政,陈奎生,陈芙蓉,张振,王磊.食管癌组织中GLUT_1和HIF-1α蛋白表达与癌细胞浸润转移及预后的研究[J].肿瘤基础与临床,2007,20(1):18-20. 被引量:5
-
3Kunkel M, Reichert TE, Benz P, et al. Ove rexpression of Glutl and increased glucose metabolism in tumors are associated with the poor prognosis in patients with oral squamous cell carcinoma. Cancer, 2003, 97(4): 1015-1024.
-
4Yamada A, Oguchi K, Fukushima M, et al. Evaluation of 2- deoxy-2-[18F] fluoro-D-glucose positron emission tomography in gastric carcinoma:relation to histological subtypes, depth of tumor invasion,and glucose transporter-1 expression. Ann NUC1 Med, 2006, 20(9): 597-604.
-
5周玉玲,邓长生.大肠腺癌组织中的Glut1和HIF-1α蛋白表达及其与癌细胞增殖的相关性[J].癌症,2005,24(6):685-689. 被引量:13
-
6Kalir T, Wang BY, Goldfischer M, et al. lmmunohistochemieal staining of GLUTI in begin, borderline, and malignant ovarian epithelia. Cancer, 2002, 94(4): 1078-1082.
-
7宋广叶,宋志宇,邵淑丽,王晓燕.GLUT-1和DNA-PK在卵巢浆液性肿瘤中的表达及临床意义[J].中国肿瘤,2007,16(11):953-955. 被引量:3
-
8Yotmes M, Ertan A, Leehago LV, et al. Human erythrocyte glucose transporter (GLUT1) is immunohistoehemically detected as a late event during malignant progression in Barrett' s metaplasia. Cancer Epidemiol Biomarkers Prey, 1997, 6(5): 303-305.
-
9Tohma T, Okazumi S, Makino H, et al. Overexpression of glucose transporter 1 in esophageal squamous cell carcinomas :a marker for poor prognosis. Dis Esophagus, 2005, 18(3 ): 185.
-
10Maria L, Rogers S, James D. Molecular and cellular regulation of glucose transporter proteins in cancer. J Cellular Physiology, 2005, 202(2): 654.
二级参考文献32
-
1Akakura N, Kobayashi M, Horiuchi I, et al. Constitutive expression of hypoxia-inducible factor-lalpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation [J]. Cancer Res, 2001,61 (17) :6548-6554.
-
2Yamakawa M, Liu LX, Date T, et al. Hypoxia-inducible factor-1 mediates of cultured endothelial cells by inducing multiple angiogenic [J]. Circ Res, 2003,93(7):664-673.
-
3Feldser D, Agani F, Iyer NV, et al. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2 [J]. Cancer Res, 1999,59(16):3915-3918.
-
4Bussink J, Kaanders JH, van der kogel AJ, et al. Tumor hypoxia at the micro-regional level:clinical relevance and predictive value of exogenous and endogenous hypoxia cell markers [J]. Radiother Oncol, 2003,67 (1): 3-15.
-
5Mendez LE, Manci N, Cantuaria G, et al. Expression of glucose transporter-1 in cervical cancer and its precusors [J].Gynecol Oncol, 2002,86(2): 138-143.
-
6Zhong H, DeMarzo AM, Laugher E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancers and their metastases [J]. Cancer Res, 1999,59(22) :5830-5835.
-
7Kunkel M, Reichert TE, Benz P, et al. Overexpression of Glut-1 and increased glucose metabolism in tumors are associated with a poor prognosis in patients with oral squamous cell carcinoma [J]. Cancer, 2003,97(4): 1015-24.
-
8Wang BY, Kalir T, Sabo E, et al. Immunohistochemical staining of GLUT1 in benign,hyperplastic,and malignant endometrial epithelia [J]. Cancer, 2000,88(12): 2774-2781.
-
9Haber RS, Rathan A, Weiser KR, et al. GLUT1 glucose transporter expression in colorectal carcinoma:a marker for poor prognosis [J]. Cancer, 1998,83 (1): 34-40.
-
10Ogawa J, Inoue H, Koide S. Glucose-transporter-type-1 -gene amplification correlations with sialyl-Lewis-X synthesis and proliferation in lung cancer [J]. Int J Cancer, 1997,74(2):189-192.
共引文献37
-
1黎曙光,欧雄书,梁爱霞,邱桂梅.内镜色素染色对早期食管癌及非典型增生的诊断[J].中国误诊学杂志,2004,4(7):1023-1024. 被引量:1
-
2张双红,朱萱.早期食管癌诊断研究进展[J].国外医学(肿瘤学分册),2003,30(6):450-452. 被引量:13
-
3屠新华,吴清明,王强.Lugol′s液染色及多点活检对早期食管癌的诊断[J].中国误诊学杂志,2005,5(3):498-499.
-
4李建平.内镜下碘染色对食管非典型增生及早期癌的诊断价值[J].临床误诊误治,2005,18(8):607-607.
-
5邱玉艳.内镜下双重染色对早期食管癌的诊断价值(附64例报告)[J].哈尔滨医药,2005,25(4):42-42.
-
6吴永兵,徐建军.食管癌诊断的研究[J].实用临床医学(江西),2006,7(4):150-152. 被引量:2
-
7赵华,夏红卫,陈珺.复合染色对早期食管癌诊断价值评价[J].郧阳医学院学报,2006,25(2):116-116. 被引量:1
-
8童强,张卫国,王强,王小虎,吴清明.超声微探头联合卢戈(lugol)液染色诊断早期食管癌及癌前病变61例[J].临床内科杂志,2006,23(8):532-533. 被引量:1
-
9李辉,阎天生,张晓娜.食管癌早期诊断的研究进展[J].河北医药,2006,28(8):755-757. 被引量:7
-
10冯春来,王翎,董宁征.缺氧对肺腺癌细胞HIF-1α、GLUT-1、MMP-2表达影响的研究[J].肿瘤,2007,27(6):445-448. 被引量:1
-
1吉文红,姚健,李奇志,杨雪芬.内镜黏膜下剥离术治疗食管癌前病变的临床护理[J].中国社区医师,2015,31(28):145-146.
-
2陈霞,许力行,卢平,李宁,曾新群,张艾,崔忠邦.52例肾脏实质性肿瘤的影像学诊断[J].贵阳医学院学报,1997,22(3):298-299.
-
3邓平,郭风云.光动力学疗法治疗114例食管癌前病变的临床护理[J].中国激光医学杂志,2005,14(4):270-270.
-
4韩曼彤,陈念德,冼兆新.乳腺增生病的彩色多普勒超声诊断与病理对照分析[J].放射学实践,2001,16(1):34-36. 被引量:5
-
5郑兴,章同华,陈思聪.血管紧张素转化酶抑制剂治疗心力衰竭的药理作用及临床应用[J].现代诊断与治疗,1995,6(4):215-218. 被引量:1
-
6吕海霞,王美峰,吴慧萍.食管癌前病变行内镜下黏膜剥离术并发食管胸膜瘘1例临床护理[J].齐鲁护理杂志,2016,22(8):102-104.
-
7叶建红,舒晓春,陈苹,麦伟华,郎江明.代谢综合征患者葡萄糖代谢率与血浆脂联素及瘦素水平变化的关系[J].中华医学杂志,2011,91(16):1088-1091. 被引量:9
-
8宋段,臧国军.血管母细胞瘤影像诊断分析[J].内蒙古医学杂志,2006,38(1):38-39.
-
9穆红,刘明洲,李雪彪.血管紧张素Ⅰ转化酶基因多态性检测及其临床意义[J].临床检验杂志,1999,17(5):292-293.
-
10阎玲,杜艳林,王泽民.中医辨证治疗肠上皮化生[J].中国现代医药杂志,2009,11(2):119-120. 被引量:5