灵芝孢子对原发性肝癌术后肝功能影响的研究

Study of Ganodem a lucidum treatment on liver function after hepatic resection in patients with hepatocellular carcinoma

目的评估灵芝孢子对原发性肝癌术后肝功能的影响。方法 80例原发性肝癌切除术后患者随机分为对照组(常规护肝治疗)和治疗组(对照组基础上加灵芝孢子治疗),各40例。术后1d、3d、7d动态监测肝功能指标(ALT、AST、TBIL、ALB、PT)变化,比较灵芝孢子治疗对原发性肝癌术后肝功能的影响。结果术后第1天,治疗组和对照组均出现较明显的肝功能损害。经1周治疗后,治疗组较对照组肝功能明显改善(P=0.032),无一例出现肝功能不全,而对照组2例出现肝功能不全。两组术后并发症和药物不良反应无明显差异(P分别为0.453、0.874)。结论灵芝孢子可以较好地改善原发性肝癌患者术后肝功能的损害,改善患者的预后。

Objective To evaluate Ganodem a lucidum （GAL） treatment on liver function after hepatic resection in patients with hepatocellular carcinoma （HCC）. Methods Eighty patients with HCC undergoing hepatectomy were randomly divided into GAL therapy group （40 cases） and conventional therapy group （40 cases）. The postoperative liver function tests of one week （ 1 d, 3 d, and 7 d） for two groups were assessed. Results There were obvious impairments of liver function at first day after hepatic resection in two groups. After a week of protective treatment for liver injury after hepatectomy, the liver function of GAL treatment group was significantly improved comparing to that of conventional treatment group （P = 0.032）. Two cases in conventional treatment group were manifested with liver dysfunction, but no one in GAL treatment group. There were no significant differences in complications of operation （P = 0.453） and side-effects of drug （P = 0.874） between the two group. Conclusion The GAL treatment had favourable efficacy on reducing impairment of liver function after hepatic resection in patients with HCC.