一个新的环五肽化合物的合成、纯化与表征

Synthesis,purification and indentation of a new cyclic pentapeptide

采用"2+3"的合成策略,以亮氨酸为起始原料,设计较优合成路线,全合成了一个新的环五肽化合物,它是具有抗肿瘤化合物Glaxamide的类似物。该化合物通过液相合成法合成,环合收率达52.3%。使用反相HPLC对其进行分离纯化,得到纯度超过99%的目标产物。

A new cyclic pentapeptide was totally synthesized starting with leucine,which was an analogue of a natural anti- tumor cyclic pentapeptide Glaxamide. It was synthesized by liquid method. The efficiency of cyclization is 52.3%. Re- verse phase HPLC was used to purify the cyclic peptide,get- ting a compound whose purification is above 99%.