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选择性氧化白桦脂醇制备桦木酮酸 被引量：2

Synthesis of betulonic acid by selective oxidation of betulin
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摘要 以商业化供应的天然产物白桦脂醇为原料,首先经高价碘试剂IBX选择性氧化生成桦木酮醛,然后经四丁基高锰酸铵氧化以86%的总收率制得标题化合物。氧化剂IBX可以方便、有效地回收并再循环。该方法操作简便,具有潜在的工业化前景。 With commercially natural product betulin as a starting material,betulonie acid was prepared efficiently by a combination of selective oxidation with IBX, further oxidation with n-Bu4NMnO4. The target compound, betulonic acid,was obtained in 86% yield. The method is easy to operate with good yield,and lends itself very well to industrial scale meth- odology.
作者 李慧 穆秋超 刘婷 徐军
机构地区 华东师范大学科学与技术跨学科高等研究院
出处 《化学试剂》 CAS CSCD 北大核心 2012年第6期493-496,共4页 Chemical Reagents
关键词 桦木酮酸 白桦脂醇 五环三萜 氧化 betulonic acid betulin pentacyclic triterpenoids oxidation
分类号 O622.4 [理学—有机化学]
  • 相关文献

参考文献27

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共引文献10

同被引文献23

  • 1马慧丽,姚军,陈慧.桦木酸制备的研究进展[J].现代中西医结合杂志,2005,14(4):551-552. 被引量：7
  • 2梁侨丽,龚祝南,闵知大.地胆草三萜成分的研究[J].中国药学杂志,2007,42(7):494-496. 被引量：28
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  • 4LEOPOLDO C, MARIANA V, IDA C, et al. Preparation of betulinic acid derivatives by chemical and biotransformation methods and determination of cytotoxicity against selected cancer cell lines [ J ]. European Journal of Medicinal Chemistry, 2013,68 ( 1 ) : 121 -131.
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引证文献2

二级引证文献4

化学试剂
2012年 第6期

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