趋化因子受体5基因启动子单核苷酸多态性与HIV易感性关系的Meta分析

Meta analysis on the association between the single nucleotide polymorphism in CCR5 gene promoter and HIV infection

目的:探讨趋化因子受体5(CCR5)基因启动子单核苷酸多态性(SNPs)与HIV易感性的关系。方法:在Pubmed等数据库检索有关CCR5基因启动子SNPs与HIV易感性的病例对照研究,选取文献,提取相关数据,用Stata10.0对数据进行Meta分析。结果:按照纳入和排除标准,共纳入8个病例对照研究,病例组共983例,对照组共1274例。分析的CCR5基因启动子SNPs位点共4个(59029A/G、59353T/C、59356C/T和59402A/G)。59029A/G和59353T/C位点的研究间异质性较小,使用固定效应模型。59029G等位突变的合并OR值及其95%CI是1.07(0.90～1.07),59353C等位突变合并的OR值及其95%CI是0.95(0.81～1.11)。59356C/T和59402A/G位点的研究间异质性较大,使用随机效应模型。59356T等位突变的合并OR值及其95%CI是1.34(0.86～2.11),59402G等位突变合并的OR值及其95%CI是0.88(0.63～1.23)。结论:CCR5基因启动子的SNPs与HIV的易感性可能没有关系。

Objective To explore the association between the single nucleotide polymorphism （SNPs） in CCR5 gene promoter and HIV infection. Methods All case-control studies about the association between the SNPs in CCR5 gene promoter and HIV infection in the Pubmed database were searched. Literatures were selected to extract the relevant data, which were used for Meta-analysis by Stata 10.0. Results Eight case-control studies with a total of 983 cases and 1 274 controls were included. 4 kinds of the SNPs sites in CCR5 gene promoter were analyzed, including 59029A/G, 59353T/C, 59356C/T, and 59402A/G loci. Fixed effect model was applied to analyze 59029A/G and 59353T/C because of the smaller heterogeneity. Meta-analysis showed that 59029G and 59353C allele mutations were not related to HIV infection （OR = 1.07, 95%CI 0.90 to 1.07 ; OR = 0.95, 95%CI 0.81 to 1.11 ）. Random effect model was applied to analyze 59356C/T and 59402A/G because of the larger heterogeneity. The results showed that the overall OR of 59356C/T and 59402A/G were 1.34 （95%CI 0.86 to 2.11） and 0.88 （95%CI 0.63 to 2.11）. Conclusions The SNPs in CCR5 gene promoter was not likely related to HIV infection