原发性肝癌人群中环氧化物水解酶基因多态性的研究

Genetic polymorphism of epoxide hydrolase and suscetibility to primary hepatocellular carcinoma

目的:探讨原发性肝癌人群中环氧化物水解酶基因多态性与肝癌发生发展的关系。方法:以广西壮族自治区人民医院2008年10月至2010年10月收治的肝癌患者与健康体检者各150名为研究对象,利用限制性片段长度多态性检测法检测研究对象该酶的基因多态性,进行对比分析。结果:环氧化物水解酶基因多态性型别在两组研究对象中出现的频率差异无显著性(P>0.05);变异等位基因出现频率与以往结果相一致。结论:环氧化物水解酶基因多态性与肝癌的发生发展无明确的相关关系。

Objective To investigate the role of genetic polymorphisms of epoxide bydrolase in patients with hepatocellular carcinoma. Methods Study was carried out in the People＇s Hospital of Guangxi Zhuang Autonomous Region, Guangxi, China. A total of 150 hepatocellular carcinoma patients and 150 healthy individuals were voluntarily recruited and assigned into two study groups. Genetic polymorphisms of epoxide hydrolase were identified by RFLP. Results In the two groups, frequencies of two genetic polymorphisms are consistent with previously reported genotype frequencies. And no significant difference of frequencies were detected among the different polymorphism alleles in EPHX-Tyrl13His,His139Arg between two groups. Conclusion Genetic polymorphisms of epoxide hydrolase are not associated with hepatocarcinogenesis.