妊娠期梅毒感染对婴幼儿生长发育影响

Influence of pregnant syphilis on infant growth and development

目的通过对妊娠感染梅毒孕妇所分娩的婴幼儿体格生长发育情况调查,探讨妊娠梅毒对婴幼儿生长发育的影响。方法对2008年1月—2009年12月在浙江省舟山市妇幼保健院住院的妊娠梅毒孕妇分娩的43名活产婴幼儿进行体格生长发育监测和随访调查。结果梅毒感染孕妇所生婴幼儿生长发育情况与2006年WHO标准比较,各月龄的体重(42 d～18月龄)、身高(42 d男婴、出生～12月龄女婴)及头围(女婴42 d、男婴出生、42 d、6月、12月龄)差异有统计学意义(P<0.05),均高于WHO标准;与中国7岁以下儿童生长发育标准比较,各月龄的体重(男女婴42 d、女婴的9月、12月龄)、身高(男女婴42 d、男婴出生时)及头围(出生及42 d)差异有统计学意义(P<0.05),均高于平均标准值;孕期接受正规抗梅毒治疗组所生的婴幼儿各项发育指标均高于非正规治疗组,但差异无统计学意义。结论梅毒感染孕妇所生正常婴幼儿生长发育整体状况较好,但随月龄增加生长速度明显趋缓,建议建立综合防治措施,确保婴幼儿体格发育正常。

Objective To explore the influence of pregnant syphilis on infant growth and development.Methods The growth and development state of 43 infants with mothers suffering from pregnant syphilis and giving the birth to their children in Maternnal and Child Care Hospital of Zhoushan city during the year of 2008-2009 were investigated.Results Compared with the standard of growth and development in 2006 by World Health Organization（WHO）,the weight（42 day to 18 months）,height（at 42 day for male and 42 day to 12 months for female）,and head circumference（at 42 day for female,at birth,42 day,6 months,and 12 months for male）of the infants with pregnant syphilitic mothers were higher than the reference（P0.05）.Compared with the standards of infants aged from 0 to 7 years in China,the weight（at 42 day for male and at 9,12 month for female）,height（at 42 day for male and female and at the birth for male）,and head circumference（at 42 day and the birth for male and female） of the infants with pregnant syphilis mothers were higher than the reference（P0.05）.The growth and development of the infants with mothers suffering from pregnant syphilis and receiving formal anti-syphilis treatment were better than those of the infants with pregnant syphilis mothers with informal treatment but the differences were not statistically significant.Conclusion The growth and development status of the infants with pregnant syphilitic mothers were generally good but their growth was slowed down with the increase of age,therefore,comprehensive prevention and control measures should be taken among the infants.