支气管激发试验在咳嗽变异性哮喘诊断中的作用

Effect of Bronchial Provocation Test in Diagnosis of Cough Variant Asthma

目的探讨支气管激发试验(BPT)在咳嗽变异性哮喘(CVA)诊断中的作用及临床意义。方法对231例慢性咳嗽患者进行乙酰甲胆碱BPT,检测其气道高反应性。结果 231例慢性咳嗽患者中,BPT阳性117例,阴性114例,阳性率50.65%;结合进一步检查及治疗效果,确诊为咳嗽变异性哮喘(CVA)110例,其余7例BPT阳性慢性咳嗽患者中5例为感染后咳嗽,2例为慢性支气管炎咳嗽。BPT诊断CVA特异度为94.02%。结论CVA是慢性咳嗽主要原因,对不明原因的慢性咳嗽患者应及时进行BPT,筛查CVA患者,利于早期诊断、正确治疗,防止其发展为典型哮喘。

Objective： To investigate the bronchial provocation test （BPT） and its clinical significance in the di- agnosis of cough variant asthma （CVA）. Methods： 231 patients with chronic cough were given the methacholine BPT to detect the airway hyperresponsiveness. Results： In 231 cases of chronic cough patients, BPT was positive in 117 cases and that was negative in 11d cases. The positive rate was 50.6%. Combined with the effect of further examination and treatment,diagnosed with CVA of 110 cases of the remaining 7 cases of BPT-positive patients with chronic cough 5 cases of cough after infection, 2 cases of chronic bronchitis and cough. BPT diagnosis of CVA specificity was 94.0%. Conclusion： CVA is the leading cause of chronic cough in patients with unexplained chronic cough should be promptly carried out BPT with screening in patients with CVA which can be early diagnosis and proper treatment to prevent the development of typical asthma.