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苦碟子注射液联合注射用甲氯芬酯治疗糖尿病伴脑梗死的临床观察 被引量:1

Clinical Observation of Ixeris sonchifolia Injection Combined with Meclofenoxate in the Treatment of Diabetic Patients with Cerebral Infarction
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摘要 目的:观察苦碟子注射液联合注射用甲氯芬酯治疗糖尿病伴脑梗死的临床疗效。方法:将120例糖尿病伴脑梗死患者随机均分为2组,2组均给予常规治疗,并给予注射用甲氯芬酯0.5g加入0.9%氯化钠注射液中静脉滴注,qd;治疗组在此基础上给予苦碟子注射液40mL加入0.9%氯化钠注射液中,静脉滴注,qd。治疗2周后,观察2组疗效及安全性。结果:治疗组总有效率(88.3%)显著高于对照组(76.7%)(P<0.05),神经功能缺损评分显著低于对照组(P<0.05)。治疗组血液流变学指标、脑血流量等均优于对照组(P<0.05)。2组均未见不良反应发生。结论:苦碟子注射液联合甲氯芬酯治疗糖尿病伴脑梗死疗效可靠,安全性较好。 OBJECTIVE: To observe clinical efficacy of Ixeris sonchifolia injection combined with meclofenoxate in the treatment of diabetic patients with cerebral infarction. METHODS: 120 type 2 diabetes patients with cerebral infarction were randomized into 2 groups, and they were given conventional treatment and intravenous infusion of meclofenoxate 0.5 g added to 0.9% sodium chloride injections once a day; treatment group was additionally given intravenous infusion of L sonchifolia injection 40 mL added to 0.9% sodium chloride injection once a day. The therapeutic efficacies of 2 groups were observed after 2 weeks. RE- SULTS: The total effective rate of treatment group (88.3%) were all obviously higher than those of control group (76.7%) (P〈 0.05), and the score of neurologic impairment were lower than control group (P〈0.05). The hemorheology, cerebral blood flow of treatment group was better than control group (P〈0.05). There was no ADR found in both groups. CONCLUSION: 1. sonchifolia injection combined with meclofenoxate is reliable in the treatment of diabetes mellitus complicating with cerebral infarction.
作者 梁金斌 王斌
出处 《中国药房》 CAS CSCD 2012年第24期2247-2249,共3页 China Pharmacy
关键词 糖尿病 脑梗死 苦碟子注射液 注射用甲氯芬酯 Diabetes mellitus Cerebral infarction lxeris sonchifolia injection Meclofenoxate injection
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