清开灵注射液致不良反应104例分析

Analysis of 104 Cases of Qingkailing Injection Induced Adverse Drug Reactions

目的:探讨清开灵注射液致不良反应(ADR)的一般规律及特点,促进临床合理用药。方法:采用回顾性研究方法,对2006年1月-2010年12月绍兴市药品不良反应监测中心收集的104例清开灵注射液致ADR病例报告进行分析。结果:多数ADR出现在用药后30min内,以0～10岁年龄组发生率最高。结论:临床应严格掌握清开灵注射液的适应证,警惕儿童用药,避免联合用药,严格控制滴速,以减少ADR的发生。

OBJECTIVE： To investigate the regularity and characteristics of adverse drug reactions induced by Qingkailing injection, and to promote rational drug use in the clinic. METHODS： By using retrospective study, 104 cases of adverse drug reaction induced by Qingkailing injection collected by Shaoxing ADR Monitoring Center were analyzed during Jan. 2006--Dec.2010. RESULTS： Most adverse drug reactions occurred within 30 min after administration.The incidence of adverse drug reactions of 0H 10-year-old age group was the highest. CONCLUSION： The clinic should be alert to children＇s medication and strictly master the indications of the Qingkailing injection to avoid drug combination, strictly control speed and reduce the incidence of adverse drug reactions.