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TERC基因在肺鳞状细胞癌中的表达

The Expression of TERC Gene in the Spuamous Cell Carcinoma
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摘要 目的:探讨端粒酶RNA(TERC)基因在肺鳞状细胞癌组织中的表达。方法:RT-PCR法检测TERC基因水平的表达情况。结果:肺鳞状细胞癌组织中TERC基因的表达高于癌旁正常组织。结论:TERC基因在肺鳞状细胞癌组织中表达上调,表明其可能参与了肺癌的发生发展,为恶性肿瘤的早期诊断和治疗提供理论支持。 t Objective: To investigate the expression of the telomerase RNA (TERC) gene in lung squamous cell carcinoma. Methods : RT - PCR were used to determine the gene expression level for TERC. Results : Compare with the adjacent normal tissue, the expression of TERC gene of lung squamous cell carcinoma is higher. Conclusions: The upregulation of TERC gene in the lung squamous cell carcinoma is involved in lung cancer development. This research can provide theoretical support to the early diagnosis and treatment of malignant tumors.
作者 蔡日丹
出处 《航空航天医学杂志》 2012年第5期513-514,共2页 Journal of Aerospace medicine
关键词 TERC基因 肺鳞状细胞癌 端粒酶 TERC gene lung squamous cell carcinoma telomerase
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参考文献7

  • 1Blackburn E H.Structure and function of telomeres.Nature,1991,350:569-573.
  • 2Parker S I,Toung T,Bolden S.Cancer statistics,1996.CA Cancer J Clin,1997,47:5227.
  • 3卫立辛,吴孟超.端粒酶:肿瘤治疗研究的新希望[J].中国肿瘤生物治疗杂志,2006,13(5):325-328. 被引量:20
  • 4李贺,张晓伟,张宗玉.端粒酶与肿瘤关系的研究进展[J].老年医学与保健,2001,7(3):181-183. 被引量:3
  • 5Yang G F,Xian R R,Y L I,et al.Telomerase l′everse transcriptase expression elevated by avian leukosis virus integration in B cell lymphomas.Proc Nail Acad Sci USA,2007,104(48):18952-18957.
  • 6Racz A,Brass N,Heckel D,et al.Expression Analysis of Genes at 3q26-q27 Involved in Frequent Amplification in Squamous Cell Lung Carcinoma.EurJ Cancer,1999 Apr,35 (4):64 1-6.
  • 7Giuseppe Pelosi,Barbara Del Curto,et al.3q26 Amplification and Polysomy of Chromosome 3 in Squamous Cell Lesions of the Lung:A Fluorescence In sire Hybridization Study.Clin Cancer Res 2007,13 (71) April 1,2007:1995-2004.

二级参考文献52

  • 1Feng J, Funk WD, Wang SS, et al. The RNA component of human telomerase. Science, 1995, 269:1236 - 1241.
  • 2Weinberg RA. Telomeres, Bumps on the road to immortality. Nature,1998, 396:23 ~ 24.
  • 3Holt SE, Aisner DL, Shay JW. Lack of cell cycle regulation of telomerase activity in human cells. PNAS, 1997, 94(20): 10687 ~ 10692.
  • 4Zhu XL, Kumar R, Mandal M, et al. Cell cycle -dependent modulation of telomerase activity in tumor cells. Prcc Natl Acad Sci USA, 1996,93:6091 ~ 6095.
  • 5Greider CW. Telomere length regulation. Annu Rev Biochem, 1996,65337 ~ 65353.
  • 6Pennisi EA. Possible new partner for telomerase. science, 1998, 282:1395 - 1397.
  • 7Harrington L, McPhail T, Mar V, et al. A mammalian telomeraseassociated protein. Science, 1997, 275:973 ~ 977.
  • 8Norton JC, Piatyszck MA, Wright WE, et al. Inhibition of human telomerase activity by peptide nucleic acids. Nat Biotechnol, 1996, 14:615 ~619.
  • 9Pitts AE, Corey DR. Inhibition of human telomerase by 2' - O - methyl -RNA. Proc Natl Acad Sci USA, 1998, 95:11549 - 11554.
  • 10Fletcher TM, Salazar M, Chen SF. Human telomerase inhibition by 7 -deaza - 2' - deoxypurine nucleoside trisphosphates. Biochemistry, 1996,35:15611 ~ 15617.

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