幽门螺杆菌感染的慢性胃炎患儿细胞因子检测及临床意义

Detection of cytokine in children with chronic gastritis infected by helicobacter pylori and its clinical significance

目的检测幽门螺杆菌(HP)感染相关的慢性胃炎外周血白细胞介素2(IL-2)、可溶性白细胞介素2受体(sIL-2R)、白细胞介素6和8(IL-6和IL-8),探讨其临床意义。方法选择84例HP感染患儿作为病例组,50例健康小儿作为对照组。IL-2、sIL-2R、IL-6、IL-8分别采用ELISA、双抗体夹心ELISA法检测。结果病例组IL-2水平均显著低于对照组(P<0.01),而sIL-2R、IL-6、IL-8水平均显著高于对照组(P<0.01)。结论 HP感染相关的慢性胃炎患儿细胞免疫功能低下且紊乱,该类患儿机体的免疫功能障碍在本病的发生中起一定作用,且参与了胃黏膜损伤的病理过程。

Objective To detect the peripheral blood interleukin - 2 （ IL - 2）, serum soluble IL - 2 receptor （ sIL - 2R）, IL - 6 and IL - 8 in children with chronic gastritis correlated with helicobacter pylori （HP）infection, and to discuss the clinical significance. Methods Totally 84 cases of chronic fastritis were chosen as the case group, and 50 healthy children were chosen as the control group. Their IL - 2 ,slL - 2R,IL - 6 and IL - 8 were detected respectively by ELISA and double - antibody sandwich ELISA. Results The IL - 2 levels of the case group were significantly lower than those of the control group（ all P 〈0.01 ） ,while the levels of slL - 2R, IL - 6 and IL - 8 were significantly higher than those in the latter group （ all P 〈 0.01 ）. Conclusion The cellular immune function is low and disordered in children with chronic gastritis correlated with HP infection. The immune dysfunction plays a certain role in the development of this disease and takes part in the pathological process of gastric mueosal injury.