血浆巨噬细胞游走抑制因子和颈动脉斑块性质与进展性脑梗死的关系

Relation of plasma macrophage MIF with carotid plaque unstability and progressive cerebral infarction

目的探讨血浆巨噬细胞游走抑制因子(macrophage migration-inhihitory factors,MIF)水平、颈动脉斑块性质与进展性脑梗死患者的关系。方法选择急性前循环脑梗死患者106例,根据临床表现分为进展性脑梗死组(进展组)56例和非进展性脑梗死组(非进展组)50例;另选健康体检者40例为对照组。采用ELISA法检测血浆MIF,同时行颈动脉多普勒超声检查。根据斑块性质,脑梗死患者又分为无斑块26例、稳定斑块40例和不稳定斑块40例,并进行MIF比较。结果进展组症状相关侧颈动脉斑块以不稳定斑块为主,占44.6%;与非进展组MIF(19.50±4.66)μg/L和对照组(23.06±5.10)μg/L比较,进展组MIF(26.24±6.08)μg/L明显升高,差异有统计学意义(P<0.05);脑梗死不稳定斑块、稳定斑块、无斑块患者MIF分别为(26.48±6.12)μg/L(23.45±5.04)μg/L、(21.12±4.53)μg/L,差异有统计学意义(P<0.05)。结论血浆MIF水平的升高和颈动脉斑块不稳定性与进展性脑梗死的发生密切相关。

Objective To study the relation of plasma macrophage migration-inhibitory factors （MIF） with carotid plaque unstability and progressive cerebral infarction（PCI）. Methods One hundred and six patients with acute anterior circulation cerebral infarction were divided into PCI group（n=56）and non-PCI group（n= 50）according to their clinical manifestations. Forty healthy subjects served as a control group. Their plasma MIF levels were measured by ELISA. Of the 106 patients who underwent carotid Doppler ultrasonography, 26 were diagnosed with no plaque,40 with stable plaques,and 40 with unstable plaques. Their MIF levels were compared. Results Unstable plaques were mainly found in PCI group, accounting for 44.6 %. The plasma MIF level was significantly higher in PCI group than in non-PCI group and control group（26.24±6.08 ug/L vs 19.50±4.66 ug/L and 23.06±5.10 ug/L,P〈0.05）. The plasma MIF level was 26.48±6.12 ug/L, 23.45 ± 5.04 ug/L, and 21.12 ± 4.53 ug/L, respectively, in patients with unstable, stable, and no plaques（P〈0. 05）. Conclusion High plasma MIF level is closely related with carotid plaque unstability and PCI.