颈动脉内膜中层厚度在老年人群心脑血管事件中的评估价值

Value of carotid intima-media thickness assessment for cardiocerebral vascular events in elderly subjects

目的探讨老年人群中性别对颈动脉内膜中层厚度(IMT)的影响以及颈动脉IMT与心脑血管事件的相关性。方法选择老年患者147例,男71例,女76例,测量身高、体重、血压、血脂,超声检测颈动脉IMT,并进行男女各变量比较及颈动脉IMT与心肌梗死、脑卒中相关性分析。结果女性≥80岁颈动脉IMT明显高于<80岁患者(0.93 mm vs 0.80 mm,P<0.05);而男性≥80岁与<80岁颈动脉IMT比较差异无统计学意义(P>0.05);在心肌梗死的logistic回归分析中,入选的变量有性别、年龄、TC、LDL-C、HDL-C、颈动脉IMT,结果提示,男性、年龄与心肌梗死呈正相关(P=0.006,P=0.038),TC、LDL-C、HDL-C及颈动脉IMT均移出模型。而在脑卒中的影响因素分析中,最终模型只有颈动脉IMT与脑卒中呈正相关(P=0.041)。结论本研究人群的性别、年龄与心肌梗死相关,而颈动脉IMT则与脑卒中相关。

Objective To study the effect of gender on carotid intima-media thickness （IMT）and its relation with cardiocerebral vascular events in elderly subjects. Methods One hundred and forty- seven elderly patients（71 males and 76 females）were enrolled in this study. Their body height and weight,blood pressure（BP）,blood lipid level,and carotid IMT were measured. Variations in male and female subjects were compared. Relation of carotid IMT with myoeardiac infarction（MI）and cerebral stroke was analyzed. Results The carotid IMT was thicker in females with their age 80 years than in females with their age 〈80 years（0.93 mm vs 0. 80 mm,P〈0.05）. However,no significant difference was found in carotid IMT of males with their age ≥80 or 〈80 years（P〉 0.05）. Logistic regression analysis showed that the variations of gender, age, TC, LDL-C, and HDL-C were positively related with MI（P〈0.05） ,and that the carotid IMT was positively related with cerebral stroke（P〈0.05）. Conclusion The gender and age are related with MI,while the carotid IMT is related with cerebral stroke in elderly subjects.