高迁移率族蛋白B1成为心肌缺血再灌注损伤的一个潜在治疗靶标被引量：1

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摘要高迁移率族蛋白B1为高迁移率族中的一种，是真核细胞大量存在的一类高度保守的核蛋白。高迁移率族蛋白B1除在肝、脑组织中主要存在于细胞质外，在大多数组织中存在于细胞核，是维持核小体结构、基因复制、重组和转录过程中的一种重要的调控蛋白。

作者付雯雯胡笑容江洪

机构地区武汉大学人民医院心内科

出处《中华老年心脑血管病杂志》 CAS 北大核心 2012年第6期655-657,共3页 Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基金国家自然科学基金(81100146)

关键词心肌再灌注损伤高迁移率族蛋白质类白细胞介素6 米诺环素

分类号 R541 [医药卫生—心血管疾病]

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参考文献28

1Scaffidi P, Misteli T, Bianchi ME. Release of chromatin pro tein HMGB1 by necrotic cells triggers inflammation. Nature, 2002,418:191-195.
2胡笑容,江洪.高迁移率族蛋白1在心肌缺血再灌注损伤中的作用[J].中国心血管杂志,2011,16(5):399-401. 被引量：1
3Andrassy M, Volz HC, Igwe JC, et al. High-mobility group box-1 in ischemia-reperfusion injury of the heart. Circulation, 2008,117 : 3216-3226.
4Hu X, Zbou X, He B, et al. Minocycline protects against myo- cardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Eur J Pharmacol, 2010, 638:84-89.
5Abarbanell AM, Hartley JA, Herrmann JL, et al. Exogenous high-mobility group box 1 improves myocardial recovery after acute global ischemia/reperfusion injury. Surgery, 2011,149 : 329-335.
6Hu X,Cui B,Zhou X,et al. Ethyl pyruvate reduces myocardial ischemia and reperfusion injury by inhibiting high mobility group box 1 protein in rats. Mol Biol Rep, 2012,39:227-231.
7Li W,Andrew ES,Wang H. Role of HMGB1 in cardiovascular diseases. Curr Opin Pharmacol, 2006,6:130-135.
8Muller S, Ronfani L, Bianchi ME. Regulated expression and subcellular localization of HMGB1, a chromatin protein with a cytokine function. J Intern Med, 2004,255 : 332-343.
9Naglova H, Bucova M. HMGB1 and its physiological and pathological roles. Bratisl Lek Listy, 2012,113 : 163-171.
10Harris HE, Andersson U, Pisetsky DS. HMOBI: A multi- functional alarmin driving autoimmune and inflammatory dis- ease. Nat Rev Rheumatol, 2012,8 : 195-202.

二级参考文献35

1Pfeffer MA. Left ventricular remodeling after acute myocardial infarction. Annu Rev Med, 1995, 46: 455~-66.
2Takemura G, Nakagawa M, Kanamori H, et al. Benefits of reperfusion beyond infarct size limitation. Cardiovasc Res, 2009, 83 : 269-276.
3Steffens S, Montecucco F, Mach F. The inflammatory response as a target to reduce myocardial ischaemia and reperfusion. Thromb Haemost, 2009, 102 : 240-247.
4Kilgore KS, Friedrichs GS, Homeister JW, et al. The complement system in myocardial ischaemia/reperfusion injury. Cardiovasc Res, 1994, 28: 437-444.
5Birdsall HH,Green DM, Trial J, et al. Complement C5a, TGF- beta 1, and MCP-1, in sequence, induce migration of monocytes into ischemie canine myocardium within the first one to five hours after reperfusion. Circulation, 1997, 95: 684-692.
6Dhalla NS,Elmoselhi AB, Hata T, et al. Status of myocardial antioxidants in ischemia-reperfusion injury. Cardiovasc Res, 2000, 47 : 446-456.
7Frangogiannis NG,Smith CW, Entman ML. The inflammatory response in myocardial infarction. Cardiovasc Res, 2002, 53: 31-47.
8Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med, 2007, 357: 1121-1135.
9Scaffidi P,Misteli T, Bianchi ME. Release of chromatin protein HMGBI by necrotic ceils triggers inflammation. Nature, 2002, 418 : 191-195.
10Yamada S, Maruyama I. HMGB1, a novel inflammatory cytokine. Clin Chim Acta, 2007, 375 : 36-42.