摘要
目的探讨婴幼儿视网膜母细胞瘤的影像特征与灌注化疗效果的相关性。方法回顾性分析28例36眼视网膜母细胞瘤患儿经导管眼动脉灌注化疗(TOAC)前、后的CT、B超的影像资料,并依据CT特征进行分组。每隔4～6周进行一次化疗,所有病例进行了2～4次化疗。利用B超测得化疗前和前两次化疗后的肿物平均厚度,并分别对每组病例的化疗前、后肿瘤缩小差值进行统计学分析,观察相互之间是否存在相关性。结果两次化疗后与化疗前对比肿物平均厚度缩小差值平均值为:Ⅰ组7.7 mm,Ⅱ组6.8 mm,Ⅲ组5 mm,Ⅳ组8.4 mm,Ⅴ组6.6 mm,Ⅵ组为0。对所有数据进行重复测量方差分析,结果显示:肿瘤的钙化量和非钙化程度的强化程度不一定会影响化疗效果,但灌注化疗的疗效是显著的。结论婴幼儿视网膜母细胞瘤的影像特征与灌注化疗效果不一定存在相关性;经导管眼动脉灌注化疗的效果是显著的。
Objective To study the correlation between the imaging features and infusion chemotherapy effect on retinoblastoma in children. Methods 28 cases with 36 eyes of retinoblastoma were collected, including CT scan and ultrasound B imaging data before and after Transcatheter Ophthalmic Artery Chemotherapy （TOAC）. Cases are grouped depend on the result of CT scan features. All the cases accepted TOAC raging from 2 to 4 times, with interval of 4 - 6 weeks every time. The mean thicknesses of the tumors were obtained from the measurement on the results of ultrasound including preoperative and postoperative. The statistic analyzed reduction differences of the tumor thickness are used for judging whether they have correlation. Results The mean reduction difference after the second TOAC： group 1 7.7 mm, group II 6. 8 mm, group Ⅲ 5 ram, group IV 8.4 mm, group V 6.6 mm, group VI is empty. All data indicated that the tumor＇s calcification quantity and the non -calcification strengthened degree will not necessarily affect the chemotherapy effect, but the infusion chemotherapy＇s effect is remarkable. Conclusion There is no correlation between imaging features and infusion chemotherapy effect on retinoblastoma, but the infusion chemotherapy＇s effect will be remarkable.
出处
《现代医院》
2012年第6期88-90,共3页
Modern Hospitals
