喷雾干燥氯诺昔康自微乳化制剂在兔体内的生物利用度

Bioavailability of Spray-dried Self-microemulsifying Drug Delivery System Loaded with Lornoxicam in Rabbits

以氯诺昔康片剂为参比制剂,考察了自制喷雾干燥氯诺昔康自微乳化制剂在兔体内的相对生物利用度。以吡罗昔康为内标,采用高效液相色谱法测定兔血浆中的氯诺昔康。6只家兔分别灌胃给予氯诺昔康的片剂或喷雾干燥自微乳化制剂,结果显示,其AUC分别为16 304和26 328 ng.h.ml-1,cmax分别为824和1 788 ng/ml,tmax分别为7.0和3.0 h。配对t检验分析表明AUC和cmax具有显著性差异(P<0.05),tmax具有极显著性差异(P<0.01),自微乳化制剂的相对生物利用度为161.5%。

The relative bioavailability of spray-dried self-micoremulsifying drug delivery system（SMEDDS） loaded with lornoxicam in rabbits was investigated with lornoxicam tablets as the reference preparation.The drug concentration in rabbit plasma was determined by HPLC with piroxicam as the internal standard.The pharmacokinetics in six rabbits after ig administration of the above two preparations was investigated.The main pharmacokinetic parameters of the tables and SMEDDS were as follows： AUC 16 304 and 26 328 ng·h·ml-1,cmax 824 and 1 788 ng/ml,tmax 7.0 and 3.0 h,respectively.The results of paired t test showed that there was a significant difference（P0.05） in AUC and cmax,and a very significant difference（P0.01） in tmax.The relative bioavailability of spray-dried SMEDDS loaded with lornoxicam was 161.5%.