摘要
目的综述特非那定的心脏毒性与国内外应用概况,为临床安全、合理用药提供参考。方法查阅国内外相关文献对特非那定在国内外上市及监管情况进行回顾并对其心脏毒性研究进展进行分析,对该药在我国的使用状况及出现的不良反应进行总结。结果特非那定具有较为明确的心脏毒性,在过量或血药浓度增高时更为明显,该药于20世纪九十年代末在欧美等国家撤市或限制使用,目前在我国以处方药管理,也有相关的不良反应报道。结论临床应警惕该药的不良反应,规范用药剂量及合并药物,提高临床用药的有效性和安全性。
Objective The cardiotoxicity of Terfenadine and its application profile in the world were reviewed in this article. The references of clinical rational and safe use of the drug were provided. Methods We accessed relevant literature of Terfenadine withdrawal from the market in some countries and analysed the research on the cardiac toxicity of the drug, and summarized the application and adverse reactions of this drug in China. Results Analysis showed that Terfenadine has cardiac toxicity, when overdosed or increased blood concentration the adverse reaction was easy to happen. Although the drug was withdrawn or was restricted in use in the late 1990s, Terfenadine is still used in China as prescription drug, and the adverse reactions were reported in recent years. Conclusion The clinical adverse drug reactions should be alert. The dosage and combination drugs should be specified, in order to improve the safety and effectiveness for clinical medication.
出处
《中国药物警戒》
2012年第6期347-350,共4页
Chinese Journal of Pharmacovigilance
关键词
特非那定
心脏毒性
不良反应
Terfenadine
cardiotoxicity
adverse drug reaction
