抑癌基因FBXW7与恶性肿瘤的研究进展
摘要
恶性肿瘤的发病是由多种外源性致癌物的诱导和内源性的基因表达失控的结果,其中基因的异常表达包括多种癌基因的活化和/或多种抑癌基因的失活。FBXW7基因（F框/WD40域蛋白基因）又称hCDC4,是最近发现的重要的抑癌基因，在人体细胞周期的进程、细胞的生长和分化起重要的调节作用，其缺失能引起和／或加快癌细胞增殖，不良预后增加。本文对FBXW7基因与恶性肿瘤之间关系的研究进展进行综述。1
出处
《临床医学》
CAS
2012年第1期117-118,共2页
Clinical Medicine
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