酒石酸美托洛尔治疗慢性充血性心力衰竭43例患者的疗效观察

Therapeutic effects of Metoprolol Tartaric on 43 cases of congestive heart failure

目的观察分析酒石酸美托洛尔对慢性充血性心力衰竭(CHF)患者的疗效。方法选择2010年10月～2011年10月43例慢性充血性心力衰竭住院患者,在常规心衰治疗的基础上,病情稳定者加用酒石酸美托洛尔,从小剂量开始,逐渐增量,直至达到最大耐受剂量,分析治疗前后患者血压、心率、心电图、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)、左心室射血分数(LVEF)及心功能改善情况。结果酒石酸美托洛尔治疗CHF患者血压、心率较治疗前均有明显降低,LVEF明显增加,心功能改善2级以上24例,改善1级17例,总有效率95%。结论在常规治疗基础上加用酒石酸美托洛尔治疗慢性充血性心力衰竭疗效显著。

Objective To observe and analyze the therapeutic effects of Metoprolol Tartaric on congestive heart failure （CHF）. Methods A total of 43 patients with CHF hospitalized during Oct 2010 to Oct 2011 were selected. Based on routine treatment, the patients were given Metoprole^l Tartaric addi- tionally when the stable condition. Start from the least dose until it reaches maximum tolerated dose ad- ditionally. Course of treatment was 12 months for the patients, and blood pressure, heart rate （HR） , e- lectrocardiogram（ECG）, left ventricular end diastolic dimension （LVEDd）.left ventricular end--systolicdimension （LVESd）, left ventricular ejection fraction （LVEF）, cardiac function were observed before and after treatment. Results Systolic blood pressure（SBP）, diastolic blood pressure（DBP） and heart rate （HR） of observation groups significantly lower compared with before treatment, left ventricular e-jection fraction （LVEF） significantly increased, cardiac function in patients with 24 improved level 2, and 17 improved level 1, the total effective rate of 92%. Conclusions Metoprolol Tartaric based on rou- tine medicine possesses more significant therapeutic effects on patients with congestive heart failure.