山明茶对高尿酸血症患者代谢指标及血栓前标志物的影响

Influence of Shanming Tea on metabolic indices and prethrombotic state molecular marker in patients with hyperuricemia

目的:通过观察山明茶对高尿酸血症患者血尿酸、血脂代谢指标、肾脏排泄功能及组织型纤溶酶原抑制剂(PAI-1)的影响,探讨山明茶的作用机制。方法:从前期建立的新疆地区的高尿酸血症体质调查数据库中选择70例痰湿夹瘀型体质的高尿酸血症患者,采用随机对照的原则分为治疗组和对照组各35例,两组均给予饮食运动及健康教育,治疗组另予以山明茶干预,观察治疗前后疗效积分,并对血尿酸、血脂代谢指标及组织型纤溶酶原抑制剂等指标进行比较分析。结果:在改善中医证候方面,治疗组疗效优于对照组(P<0.05);两组干预方法均可显著降低SUA(P<0.01);在改善TC、TG方面,治疗组明显优于对照组(P<0.01);两组PAI-1较治疗前明显降低(P<0.01)。结论:山明茶能明显改善痰湿夹瘀型体质高尿酸血症患者的中医证候,且有降低TC、TG的作用,并可降低SUA及PAI-1水平。

Objective： To observe the influence of Shanming Tea on blood uric acid,blood lipid metabolism indices,renal excretion function,and tissue-type plasminogen activator inhibitor-1（PAI-1） in patients with hyperuricemia（HUA）,and to study the mechanism of the effect of Shanming Tea.Methods： A total of 70 HUA patients with phlegm-dampness combined with blood stasis were selected from a database of HUA cases in Xinjiang Uyghur Autonomous Region.The patients were randomly divided into treatment group（n=35） and control group（n=35）.Both groups received diet ＆ exercise and health education,and Shanming Tea intervention was added in the treatment group.The clinical effects were evaluated based on related scores,and comparative analysis was performed on blood uric acid,blood lipid metabolism indices,and PAI-1.Results： The treatment group showed better improvement in traditional Chinese medicine（TCM） syndrome than the control group（P〈0.05）.Both groups had significantly decreased serum uric acid（SUA） after intervention（P〈0.01）.A better clinical effect was achieved in the treatment group than in the control group with respect to total cholesterol（TC） and total triglyceride（TG）（P〈0.01）.PAI-1 decreased significantly in both groups after treatment（P〈0.01）.Conclusion： Shanming Tea can significantly improve TCM syndrome in HUA patients with phlegm-dampness combined with blood stasis and decrease TC,TG,SUA,and PAI-1.