支气管哮喘与肥胖的关系探讨

Discussion on the relationship between bronchus asthma and obesity

目的比较肥胖与非肥胖哮喘患者的临床特点及严重程度,探讨哮喘与肥胖之间的潜在关系。方法随机选取疑诊哮喘患者,比较肥胖和非肥胖患者的相关特征。结果 500例疑诊哮喘(肥胖患者243例和体重正常者257例)患者纳入研究,350例经肺功能测试患有哮喘,150例患者排除哮喘诊断。与非肥胖患者相比,肥胖并患有哮喘者以男性为多,多有高血压病史及胃食管反流疾病,FEV1偏低。老年、男性、较高的FEV1易误诊为哮喘。过去12个月因急性呼吸道症状发作就诊的肥胖患者误诊为哮喘的比值比为1.95。结论与非肥胖哮喘患者相比,肥胖伴哮喘者具有较低的肺功能检查结果及更多的伴发病。因急性呼吸系统症状发作而就诊的肥胖患者更易被误诊为哮喘。

Objective To compare the clinical features and severity of obese and non-obese asthma patients,in order to discuss the relationship between bronchus asthma and obesity.Methods Suspected asthma patients were randomly selected and the clinical features of obese and non-obese patients were compared.Results 500 patients with suspected asthma（243 cases of obese patients and 257 cases of normal weight patients） were included in the study.350 cases were diagnosed with asthma by pulmonary function test,150 cases were excluded asthma diagnosis.Compared with non-obese asthma patients,the majority of obese patients were male,who had history of hypertension,gastroesophageal reflux disease and low FEV1 value.The older,male patients with high FEV1 value were easily misdiagnosed with asthma.The odds ratio was 1.95 due to acute respiratory symptoms were misdiagnosed with asthma in obese patients in the past 12 months.Conclusion Compared with non-obese asthma patients,obese patients with asthma have lower lung function test results and more complicated diseases.Obese patients with acute respiratory symptoms are more likely to be misdiagnosed with asthma.