肿瘤特异性生长因子和甲状腺球蛋白联合检测在甲状腺癌诊断中的应用

Application of serum tumor specific growth factor and thyroglobulin determination in diagnosis of thyroid carcinoma

目的探讨血清肿瘤特异性生长因子（TSGF）和甲状腺球蛋白（Tg）联合检测在诊断甲状腺癌中的临床价值。方法对2009年1月~2010年12月在我院就诊并均经术后病理确诊的36例甲状腺良性肿瘤组和36例甲状腺癌组患者的血清TSGF和Tg水平进行检测并比较。结果甲状腺癌组患者血清TSGF、Tg水平及阳性率均明显高于甲状腺良性肿瘤组患者（P〈0.05）。伴有颈部淋巴结转移的甲状腺癌患者血清TSGF、Tg阳性率均较无颈部淋巴结转移的甲状腺癌患者显著升高,两者间差异有统计学意义（P〈0.05）。结论血清TSGF、Tg检测敏感性和特异性高,有利于甲状腺癌的早期发现及判定有无复发或转移,在甲状腺癌的早期诊断中具有重要意义。

Objective To investigate the clinical value of serum tumor specific growth factor（TSGF） and thyroglobulin（Tg） determination in diagnosis of thyroid carcinoma.Methods The serum TSGF and Tg levels of 36 patients with benign thyroid tumor and of 36 patients with thyroid carcinoma by pathological diagnosis from January 2009 to December 2010 were examined and compared.Results The serum TSGF and Tg levels and positive rates in the patients with thyroid carcinoma were significantly higher than those in benign thyroid tumor（P 0.05）.In the patients with thyroid carcinoma,the serum TSGF and Tg positive rates in the patients with cervical lymph nody metastasis were remarkably higher than those in no cervical lymph nody metastasis.There were significant difference between the two groups（P 0.05）.Conclusion The serum TSGF and Tg levels determination have high sensibility and particularity.And they are propitious to early detecting and judging recrudescence or transferring of thyroid carcinoma.They have significance in early diagnosis of thyroid carcinoma.