血浆纤维蛋白原、IL-17水平与脑梗死病程相关性的研究

The relevant research between the levels of plasma FIB,IL-17 and course in patients with cerebral infarction

目的探讨血浆纤维蛋白原（FIB）、IL-17水平与脑梗死患者病程的相关性。方法对50例脑梗死患者根据头部CT或MRI病灶大小,梗死体积按Pullicino公式（长×宽×层数/2）计算进行分组：大梗死组（病灶体积〉10 cm3）,中梗死组（病灶体积4~10 cm3）,小梗死组（病灶体积〈4 cm3）;神经功能受损程度分型：按照NIHSS进行评分,重型组（30~42分）,中型组（15~29分）,轻型组（0~14分）。脑梗死组在发病24 h内采集抗凝血标本,设健康对照组20例。采用酶联免疫双抗体夹心法检则IL-17的含量,用全自动凝血分析仪检测FIB。结果大梗死组发病24 h内FIB、IL-17水平明显高于对照组（P〈0.01）,中、小梗死组发病24 h内FIB、IL-17水平高于对照组（P〈0.05）;重型组发病24h内FIB、IL-17水平明显高于对照组（P〈0.01）,中、小型组发病24 h内FIB、IL-17水平高于对照组（P〈0.05）;大梗死组FIB、IL-17水平与小梗死组比较差异有统计学意义（P〈0.05）;重型组FIB、IL-17与轻型组比较差异有统计学意义（P〈0.05）。结论血浆FIB、IL-17水平与脑梗死病情的严重程度密切相关,定期检查FIB、IL-17水平对预防脑梗死很有价值。

Objective To explore the correlation of FIB,IL-17 with the patients with cerebral infarction.Methods According to the infarction size of CT or MRI of head,the 50 patients with cerebral infarction were divided into three group： the large（10 cm3）,middle（4~10 cm3）and small（4 cm3） area infarction;According to the damage degree of nerve function,were divided into three type： the serious（30~42 scores）,moderate（15~29 scores） and mild（0~14 scores） NIHSS scores,20 healthy persons were served as control group.To collect anticoagulant specimens within 24 h,IL-17 were measured by two-layer antibody sandwith enzyme linked immunosorbent assay.FIB were measured by blood coagulation function full-automatic analyser.Results The levels of FIB,IL-17 of the large group obviously higher than control group（P 0.01）,the levels of FIB,IL-17 of middle and small group higher than control group（P 0.05）;the levels of FIB,IL-17 of the serious type obviously higher than control group（P 0.01）,the levels of FIB,IL-17 of moderate and mild type group higher than control group（P 0.05）;the levels of FIB,IL-17 of the large group compared with small group were difference（P 0.05）;the levels of FIB,IL-17 of the serious type compared with mild type group were difference（P 0.05）.Conclusion It is closely relevant that serious intensity of cerebral infarction and the levels of plasma FIB,IL-17.There is great value to regular test FIB,IL-17 to prevent from cerebral infarction.