米非司酮对子宫内膜异位症患者血液流变学及子宫动脉血流动力学指标的影响

Influence of Mifepristone for indexes of hemorheology and uterine artery hemodynamics of patients with endometriosis

目的研究米非司酮对子宫内膜异位症患者血液流变学及子宫动脉血流动力学指标的影响。方法选取2008年10月～2011年3月于本院进行治疗的74例子宫内膜异位症患者为研究对象,将其随机分为对照组和观察组各37例,对照组采用腹腔镜手术进行治疗,观察组在此基础上加用米非司酮进行治疗,后将两组患者治疗前及治疗后6个周及12个周的血液流变学及子宫动脉血流动力学指标进行研究及比较。结果观察组的全血黏度、全血还原黏度、血浆黏度及红细胞各指标均低于对照组,左右子宫动脉最大血流速度大于对照组,搏动指数、阻力指数小于对照组,差异均有统计学意义(均P<0.05)。结论米非司酮可显著改善子宫内膜异位症患者发热血液流变学及子宫动脉血流动力学指标,对于患者康复起着积极的作用。

Objetive To study the influence of Mifepristone for indexes of hemorheology and uterine artery hemodynamics of patients with endometriosis.Methods 74 patients with endometriosis in our hospital from October 2008 to March 2011 were selected as research object,and they were randomly divided into control group and observation group,with 37 cases in each group.The control group was treated with laparoscopic operation,the observation group was treated with Mifepristone based on the treatment,then the indexes of hemorheology and uterine artery hemodynamics of two groups before and after the treatment at sixth and twelfth week were studied and compared.Results The whole blood viscosity,whole blood reduction viscosity,plasma viscosity and each index of erythrocyte were all lower than those of control group,left and right uterine artery maximum blood flow velocity were bigger than those of control group,pulsatility index and resistance index were all smaller than those of control group,there were significant differences（P 0.05）.Conclusion The Mifepristone can significantly improve the indexes of hemorheology and uterine artery hemodynamics of patients with endometriosis,and it plays an active role in the rehabilitation of patients.