过敏性鼻炎儿童血清维生素D水平的临床研究

Clinical research on the serum levels of vitamin D in the children with allergic rhinitis

目的探讨血清维生素D水平与过敏性鼻炎的相关性。方法选择海珠区妇幼保健院2～6岁儿童100例,其中健康儿童50例为对照组,患过敏性鼻炎儿童50例为实验组,分别使用串联质谱仪检测其血清维生素D水平。结果对照组总维生素D水平为(32.87±4.67)ng/mL,其中维生素D2水平为(3.84±4.21)ng/mL,维生素D3水平为(29.96±2.52)ng/mL;实验组总维生素D水平(23.00±2.00)ng/mL,其中维生素D2水平(3.62±3.04)ng/mL,维生素D3水平(20.38±2.32)ng/mL。两组总维生素D及维生素D3水平比较差异均存在统计学意义(均P<0.05)。结论过敏性鼻炎儿童血清维生素D水平比正常儿童偏低,且以维生素D3水平偏低为主。

Objective To research the relationship between serum level of vitamin D and allergic rhinitis.Methods 100 children aged from 2 to 6 years old were divided into the experimental group and the control group,each group had 50 cases.Tandem mass spectrometry was used to detect the serum levels of vitamin D.Results Total vitamin D level of control group was（32.87±4.67） ng/mL,vitamin D2 level was（3.84±4.21） ng/mL and vitamin D3 level was（29.96±2.52） ng/mL.Total vitamin D level of experimental group was（23.00±2.00） ng/mL,vitamin D2 level was（3.62±3.04） ng/mL and vitamin D3 level was（20.38±2.32） ng/mL.There were significant differences of total vitamin D level and vitamin D3 level between the two groups（P 0.05）.Conclusion The level of total vitamin D in allergic rhinitis children is lower than that of normal children,with lower level of vitamin D3 primarily.